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Norisoboldine Norisoboldine (NOR), the main isoquinoline alkaloid present in the dried roots of Radix Linderae, may have certain anti-RA activity (70, 71), which can improve synovitis and abnormal immune status of CIA mice, and inhibit the activation of RAW264.7 macrophages by down-regulating the MAPKs signaling pathway

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Peptides were eluted by the consecutive addition and collection by centrifugation at 4,000 g for 1 min of 40 l digestion buffer, 40 l of 0.2% formic acid, and finally, 35 l 50% acetonitrile, 0.2% formic acid

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